NanoCelle D3


Optimal D3 Absorption


Increases Vitamin D3 levels

This product is Practitioner Grade. Consult your health professional before use. Alternatively, contact Medlab practitioners for advice at clinic.medlab.co. Virtual consultations for 20 minutes can be booked free of charge.

Description


Vitamin D3:

  • Essential for optimal immune function.
  • Anti-inflammatory.
  • Maintains bone health.
  • Helps calcium absorption.
  • Supports lung health.
  • Promotes healthy respiratory function.
  • Suitable for groups at increased risk of vitamin D3 deficiency.

What is NanoCelle?

NanoCelle is a unique delivery technology that is safe, effective and convenient, administered as a spray onto the oro-buccal membrane inside of the cheek.

The vitamin is in a nano-particle size so that it can be directly absorbed into the blood stream. This enables the formulation to be lower dose with higher absorption, in contrast to ingested forms.

NanoCelle has been shown to have a higher absorption rate than tablets, capsules, gel capsules, dermal patches, sublingual (under the tongue) liquid, and intramuscular injections. By avoiding the digestion pathway, this technology is beneficial for those experiencing gastrointestinal or digestion complications.

Directions of Use


 

Take 2 sprays (300 microlitre) once a day or as directed by your health professional. Spray on the inside of the cheek.

Indications


 

  • Anti-inflammatory/relieve inflammation
  • Maintain/support bone health
  • Helps enhance/promote bone mass/density
  • Vitamin D helps calcium absorption (or words of like intent) and a diet deficient in calcium can lead to osteoporosis in later life
  • Maintain/support healthy immune system function
  • Helps prevent dietary Vitamin D3 deficiency
  • Maintain/support lung health
  • Maintain/support healthy mucous membranes/mucous tissue of the respiratory tract

 

Warnings


Always read the label. Follow the directions for use. Vitamin supplements should not replace a balanced diet. Contains potassium sorbate.

Side Effects


Vitamin D3 has a low risk of side-effects when taken as directed.

Interactions


We advise NanoCelle™ D3 should not be given to patients currently taking:

  • Calcitriol medications
  • Steroid medication such as prednisone
  • Weight loss medication Orlistat
  • Cholesterol lowering medications such as Cholestyramine and Thiazide diuretics
  • Seizure medications such as Phenobarbital and Dilantin

Ingredients


Each 300 microlitre dose (2 sprays) contains


Colecalciferol

(Vitamin D3)

25 μg (1000 IU)




Excipents


Citric acid - anhydrous

(Citric acid )

1.9 mg/mL


Glycerol

(Glycerin )

105 mg/mL


Zea mays seed (kernel) embryo oil fixed

(Maize oil )

3.2467 mg/mL


PEG-40 hydrogenated castor oil

(Castor oil )

156.667 mg/mL


Mentha x piperita L. aerial parts oil ess.

(Peppermint oil )

167 μg/mL


Potassium sorbate

( )

1.067 mg/mL


Purified water

(Water )

770.032 mg/mL


Steviol glycosides

(Stevia )

500 μg/mL




Related Publications


Reactive oxygen species and their lifelong regulation of the metabolome.
Title Content
Location 6th World Congress on Targeting Mitochondria October 28–30, 2015. Berlin, Germany.
Date 2015-10-28
Authors Professor Luis Vitetta
Scientific Application for Innovative Delivery Systems: Bacteria and Nanotechnology Platforms
Title Content
Location The 5th Annual Symposium of Drug Delivery Systems Oct 20-22, 2015. Beijing, China.
Date 2015-10-20
Authors Dr. Samantha Coulson
Invitation to Chair session on Nanotechnologies for Drug Delivery Systems: Redefining the Curve - Sustainable Compound Delivery Through Nanoparticles.
Title Content
Location BIT’s 14th Annual Congress of IDDST June 16-18, 2016. South Korea
Date 2016-06-16
Authors Dr. Sean Hall

Related Clinical Trials


NanoCelle® D3
Title Content
Name NanoCelle® D3
Type Delivery Platform
About [{"layout":"text","key":"034754fa65c308d4","attributes":{"content":"

ABOUT TRIAL:<\/h3>\n\n

This study is a Vitamin D3 hormone blood level absorption study, performed in healthy adult volunteers.<\/p>\n\n

Vitamin D is a fat-soluble vitamin that is naturally present in very few foods, added to others, and available as a dietary supplement. It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis. Vitamin D is obtained from sun exposure, food, and supplements are biologically inert and must undergo two hydroxylations in the body for activation. <\/p>\n\n

Source: Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Calcium and Vitamin D. 2010.Washington, DC: National Academy Press.<\/em><\/p>\n\n

Vitamin D promotes calcium absorption in the gut and maintains adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and to prevent hypocalcemic tetany. It is also needed for bone growth and bone remodelling by osteoblasts and osteoclasts<\/p>\n\n

Source: Cranney C, Horsely T, O’Donnell S, Weiler H, Ooi D, Atkinson S, et al. Effectiveness and safety of vitamin D. Evidence Report\/Technology Assessment No. 158 prepared by the University of Ottawa Evidence-based Practice Center under Contract No. 290-02.0021. AHRQ Publication<\/em><\/p>\n","grey_section":true}}]

Formulation [{"layout":"text","key":"587649aae7e075e7","attributes":{"content":"

FORMULATION:<\/h3>\n\n

NanoCelle® D3 is a sub-micron spray applied to the oro-buccal membrane delivering 5000 I.U. in 2 actuation of the pump. The absorption characteristics of the formulation were compared to 5 other Australian Vitamin D3 formulations in a Phase 0, absorption study.<\/p>\n","grey_section":true}}]

Date started 2013-10-09
Date of HREC approval 2013-10-09
HREC name National Institute of Integrative Medicine
HREC approval ID 001/072013
ANZCTR ACTRN12616001027404
ANZCTR URL Link http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=371174&isReview=true
Study Site Medlab, Alexandria NSW Australia
Status Completed
Progression Regulatory Submission - Approved
Brand VMS
Product Family NanoCelle D3
Product Ingredient

Colecalciferol

Product Group Nanocelle
Publications and presentations Scientific Application for Innovative Delivery Systems: Bacteria and Nanotechnology Platforms , Invitation to Chair session on Nanotechnologies for Drug Delivery Systems: Redefining the Curve - Sustainable Compound Delivery Through Nanoparticles.

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